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Jantoven and Protein c, human Intravenous

Determining the interaction of Jantoven and Protein c, human Intravenous and the possibility of their joint administration.

Check result:
Jantoven <> Protein c, human Intravenous
Relevance: 22.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using protein C together with warfarin may increase the risk of bleeding. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Simultaneous administration of protein C concentrate with tissue plasminogen activators and/or anticoagulants may increase the risk of bleeding. The mechanism of interaction is unknown. Several bleeding episodes have been observed in clinical studies of protein C concentrate for which concurrent anticoagulant medication may have been responsible. However, a contributory effect by protein C cannot be completely ruled out.

MANAGEMENT: Caution is advised if protein C concentrate is used in combination with tissue plasminogen activators and/or anticoagulants. Close clinical and laboratory observation for hematologic complications is recommended. Patients should be advised to promptly report any signs of bleeding to their doctor, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References
  • "Product Information. Ceprotin (protein C)." Baxter Healthcare Corporation, Deerfield, IL.
Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

Protein c, human Intravenous

Generic Name: protein c

Brand name: Ceprotin

Synonyms: Protein C Concentrate (Human)

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle