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Jantoven and Rifampin Capsules

Determining the interaction of Jantoven and Rifampin Capsules and the possibility of their joint administration.

Check result:

Jantoven <> Rifampin Capsules

Relevance: 22.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using warfarin together with rifAMPin. This combination may reduce the effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). It is important to tell your doctor about all other medications you use including vitamins and herbs. Do not stop using any medications without talking to your doctor first.

Professional:

GENERALLY AVOID: Rifampin may decrease the anticoagulant effect of warfarin by enhancing CYP450 hepatic microsomal enzyme metabolism of warfarin.

MANAGEMENT: Concurrent use should be avoided unless no alternatives are available. The INR or prothrombin time should be monitored closely during concomitant therapy and after rifampin is discontinued. Adjustments in warfarin dosage may be needed when rifampin dosage is added, discontinued, or changed. This interaction may occur with other oral anticoagulants and with rifabutin.

References

Thijssen HH, Flin ois JP, Beaune PH "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos 28 (2000): 1284-90
O'Reilly RA "Interaction of chronic daily warfarin therapy and rifampin." Ann Intern Med 83 (1975): 506-8
Allen RJ, Almond SN, Caiolsa SM, et al "Rifampin." Drug Intell Clin Pharm 5 (1971): 364-5
Heimark LD, Gilbaldi M, Trager WF, et al "The mechanism of the warfarin-rifampin drug interaction in humans." Clin Pharmacol Ther 42 (1987): 388-94
O'Reilly RA "Interaction of sodium warfarin and rifampin." Ann Intern Med 81 (1974): 337-40
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6
Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83
Casner PR "Inability to attain oral anticoagulation: warfarin-rifampin interaction revisited." South Med J 89 (1996): 1200-3
Heimark LD, Gibaldi M, Trager WF, et al "The mechanism of the warfarin-rifampin drug interaction in humans." Clin Pharmacol Ther 42 (1987): 388-94
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Self TH, Mann RB "Interaction of rifampin and warfarin." Chest 4 (1975): 490-1
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?

Rifampin Capsules

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: Rifampin

What is Rifampin Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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