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Jantoven and Sucralfate Tablets

Determining the interaction of Jantoven and Sucralfate Tablets and the possibility of their joint administration.

Check result:

Jantoven <> Sucralfate Tablets

Relevance: 22.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using warfarin together with sucralfate may decrease the effects of warfarin. Warfarin should be administered at least 2 hours before or 6 hours after sucralfate. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Sucralfate may interfere with the absorption of warfarin in some patients and may reduce its therapeutic effect. The mechanism is unknown and clinical data have been conflicting.

MANAGEMENT: Patients should be advised to take the anticoagulant at least 2 hours before or 6 hours after the sucralfate to minimize a potential interaction. Close observation for altered anticoagulant effect is recommended. Sucralfate may interact in the same manner with other oral anticoagulants as well.

References

Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83
Braverman SE, Marino MT "Sucralfate--warfarin interaction." Drug Intell Clin Pharm 22 (1988): 913
Rey AM, Gums JG "Altered absorption of digoxin, sustained-release quinidine, and warfarin with sucralfate administration." DICP 25 (1991): 745-6
Parrish RH, Waller B, Gondalia BG "Sucralfate-warfarin interaction." Ann Pharmacother 26 (1992): 1015-6

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?

Sucralfate Tablets

Generic Name: sucralfate

Brand name: Carafate

Synonyms: Sucralfate

What is Sucralfate Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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