Jantoven and Trimethoprim Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Trimethoprim may increase the effects of warfarin. You may need more frequent monitoring of your prothrombin time or INR by your doctor to safely use both medications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Many antibacterials may potentiate the hypoprothrombinemic effect of oral warfarin and other coumarin anticoagulants. The exact mechanism is unknown but may involve inhibition of coumarin metabolism and/or depletion of certain clotting factors due to suppression of vitamin K-producing intestinal flora. Other influences such as fever, infection, malnutrition, renal impairment, age, and other concomitant underlying conditions on clotting mechanisms and anticoagulant pharmacokinetics should also be considered.

MANAGEMENT: Given the potential for clinically significant interaction and even fatality in the occasional, susceptible patient, monitoring is recommended during concomitant therapy. The INR should be checked frequently and coumarin dosage adjusted accordingly, particularly following initiation or discontinuation of the antibacterial therapy in patients who are stabilized on their anticoagulant regimen. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?

Trimethoprim Tablets

Generic Name: trimethoprim

Brand name: Primsol, Trimpex, Proloprim

Synonyms: Trimethoprim

What is Trimethoprim Tablets?