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Jevantique Lo and Sugammadex

Determining the interaction of Jevantique Lo and Sugammadex and the possibility of their joint administration.

Check result:
Jevantique Lo <> Sugammadex
Relevance: 22.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Sugammadex may reduce the blood levels and effects of norethindrone. If you are using hormonal contraceptives, you may have an increased risk of breakthrough bleeding and unintended pregnancy for the next 7 days after receiving sugammadex. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take hormone replacement for menopause, notify your doctor if you experience increased symptoms or abnormal bleeding. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADDITIONAL CONTRACEPTION RECOMMENDED: Sugammadex may decrease the free plasma concentrations and therapeutic efficacy of hormonal contraceptives. In vitro binding studies indicate that sugammadex can bind to progestogen. Sugammadex 4 mg/kg is predicted to reduce progestogen systemic exposure (AUC) by 34%. The predicted effect is lower for estrogens. According to the manufacturer, the administration of a bolus dose of sugammadex may result in reduced contraceptive effectiveness equivalent to a missed dose of the contraceptive. Clinical data have not been reported.

MANAGEMENT: Female patients of reproductive potential receiving hormonal contraceptives (whether oral or non-oral) should use an additional, nonhormonal contraceptive method or backup method of contraception (e.g., condoms and spermicides) for 7 days after sugammadex administration.

References
  • "Product Information. Bridion (sugammadex)." Merck & Company Inc, Whitehouse Station, NJ.
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Jevantique Lo

Generic Name: ethinyl estradiol / norethindrone

Brand name: femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: Jevantique Lo (HRT)

Sugammadex

Generic Name: sugammadex

Brand name: Bridion

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction