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Jevtana and Zykadia

Determining the interaction of Jevtana and Zykadia and the possibility of their joint administration.

Check result:
Jevtana <> Zykadia
Relevance: 19.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of cabazitaxel, which is primarily metabolized by the isoenzyme. However, no formal drug interaction studies have been conducted. MANAGEMENT: Concomitant use of cabazitaxel with potent CYP450 3A4 inhibitors should generally be avoided. References "Product Information. Jevtana (cabazitaxel)." sanofi-aventis , Bridgewater, NJ.

Professional:

GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of cabazitaxel, which is primarily metabolized by the isoenzyme. However, no formal drug interaction studies have been conducted.

MANAGEMENT: Concomitant use of cabazitaxel with potent CYP450 3A4 inhibitors should generally be avoided.

References
  • "Product Information. Jevtana (cabazitaxel)." sanofi-aventis , Bridgewater, NJ.
Jevtana

Generic Name: cabazitaxel

Brand name: Jevtana

Synonyms: n.a.

Zykadia

Generic Name: ceritinib

Brand name: Zykadia

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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