Juluca and Victrelis

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Boceprevir may increase the blood levels and effects of rilpivirine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with boceprevir may increase the plasma concentrations of rilpivirine. The proposed mechanism is boceprevir inhibition of the CYP450 3A4-mediated metabolism of rilpivirine. When rilpivirine 25 mg once a day and boceprevir 800 mg three times a day were given together for 11 days, mean rilpivirine peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) increased by 15%, 39% and 51%, respectively. The clinical significance of these changes is unknown. The pharmacokinetics of boceprevir were not altered.

MANAGEMENT: No dosage adjustment is required for either boceprevir or rilpivirine during concomitant use, but monitoring for potentially increased adverse effects of rilpivirine such as depression, hepatotoxicity, and prolongation of the QT interval may be advisable.

Juluca

Generic Name: dolutegravir / rilpivirine

Brand name: Juluca

Synonyms: n.a.

What is Juluca?

Victrelis

Generic Name: boceprevir

Brand name: Victrelis

Synonyms: n.a.

What is Victrelis?