Junel Fe 1.5/30 and Metoprolol Injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ethinyl estradiol may increase the blood levels of metoprolol in some patients. This can cause greater decreases in blood pressure and heart rate. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Oral contraceptives containing ethinyl estradiol may interfere with the first-pass metabolism of certain beta-blockers and increase their plasma concentrations. In one study, young, healthy female subjects receiving a low-dose ethinyl estradiol oral contraceptive (OC) demonstrated higher plasma levels of metoprolol (100 mg), oxprenolol (80 mg), and propranolol (80 mg) following single-dose administration than control subjects who were not receiving an OC. Specifically, mean metoprolol peak plasma concentration (Cmax) and systemic exposure (AUC) were 36% and 71% higher, respectively, in OC users (n=12) than in non-users(n=11); mean oxprenolol Cmax and AUC were 6% and 26% higher, respectively, in OC users (n=7) than in non-users (n=8); and mean propranolol Cmax and AUC were 19% and 42% higher, respectively, in OC users (n=7) than in non-users (n=8). Only the difference in metoprolol AUC reached statistical significance, although the difference in propranolol AUC failed to reach significance by only a narrow margin.

MANAGEMENT: Pharmacologic effects including blood pressure and heart rate changes should be monitored more closely when metoprolol, oxprenolol, and propranolol are coadministered with ethinyl estradiol oral contraceptives, and dosage adjustments made as necessary.

Junel Fe 1.5/30

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: n.a.

What is Junel Fe 1.5/30?

Metoprolol Injection

Generic Name: metoprolol

Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

Synonyms: Metoprolol

What is Metoprolol Injection?