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Junel Fe 1.5/30 and Ulipristal Acetate

Determining the interaction of Junel Fe 1.5/30 and Ulipristal Acetate and the possibility of their joint administration.

Check result:
Junel Fe 1.5/30 <> Ulipristal Acetate
Relevance: 06.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ulipristal together with norethindrone is not recommended. Combining these medications may reduce the effectiveness of both. If you are starting norethindrone for routine contraception after using ulipristal, you should wait at least 5 days to do so, and use an additional method of birth control such as condom with spermicide each time you have sex until your next menstrual period. You should discuss your contraceptive options with your healthcare provider. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration of ulipristal with combination hormonal contraceptives may reduce the efficacy of both treatments for the prevention of pregnancy. Ulipristal and the progestin component of hormonal contraceptives both bind to the progesterone receptor. Theoretically, competitive inhibition of the receptor may occur, which may diminish the effects of each on ovulation. Limited clinical data are available. When a combined oral contraceptive pill containing ethinyl estradiol-levonorgestrel 30 mcg-150 mcg was started the day after ulipristal dosing during the follicular phase, the ability of the oral contraceptive to suppress ovarian activity was not impacted, as assessed by measurement of follicle size via transvaginal ultrasound, along with serum progesterone and estradiol levels. Ovarian activity was suppressed in 61.5% (24/39) of subjects receiving ulipristal plus oral contraceptive and 62.2% (23/37) of
subjects receiving a placebo plus oral contraceptive. The incidence of ovulation was also similar between the two groups, at 33.3% (13/39) and 32.4% (12/37), respectively.

MANAGEMENT: Concomitant use of ulipristal with combination hormonal contraceptives should be avoided. After emergency contraception with ulipristal, routine contraception should be continued or initiated as soon as possible to ensure ongoing prevention of pregnancy. Patients who wish to use progestogen-containing contraceptives should do so no sooner than 5 days after taking ulipristal, and they should use a reliable barrier method of contraception until their next menstrual period.

References
  • "Product Information. ella (ulipristal)." Afaxys Inc., Charleston, SC.
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Junel Fe 1.5/30

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: n.a.

Ulipristal Acetate

Generic Name: ulipristal

Brand name: Ella, Ella

Synonyms: Ulipristal

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction