Juxtapid and Tri-Norinyl

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using lomitapide together with ethinyl estradiol. Combining these medications may significantly increase the blood levels and effects of lomitapide. You may be more likely to experience side effects such as diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage. At the same time, the absorption of ethinyl estradiol may be affected if you develop diarrhea or vomiting, which may reduce its effectiveness in preventing pregnancy. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid or limit the use of alcohol during treatment with lomitapide, and seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with weak inhibitors of CYP450 3A4 including oral contraceptives may increase the plasma concentrations of lomitapide, which is primarily metabolized by the isoenzyme. Weak CYP450 3A4 inhibitors increase lomitapide exposure by approximately 2-fold according to the product labeling.

MANAGEMENT: The maximum recommended dosage of lomitapide is 30 mg daily when used in combination with weak CYP450 3A4 inhibitors including oral contraceptives. Likewise, if oral contraceptives are initiated during treatment with lomitapide, the dosage of lomitapide may require adjustment. Patients should be advised that hormone absorption from oral contraceptives may be incomplete if vomiting or diarrhea occurs while taking lomitapide, which would warrant the use of additional contraceptive methods, especially since lomitapide may be teratogenic.

Juxtapid

Generic Name: lomitapide

Brand name: Juxtapid

Synonyms: n.a.

What is Juxtapid?

Tri-Norinyl

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Estrostep Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Taytulla, Tri-Norinyl, Zenchent, Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Tilia Fe, Tri-Legest Fe, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: Tri-Norinyl (birth control)

What is Tri-Norinyl?