Juxtapid Capsules and Norethindrone (Hormone Replacement Therapy)
Determining the interaction of Juxtapid Capsules and Norethindrone (Hormone Replacement Therapy) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using lomitapide together with norethindrone. Combining these medications may significantly increase the blood levels and effects of lomitapide. You may be more likely to experience side effects such as diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage. At the same time, the absorption of norethindrone may be affected if you develop diarrhea or vomiting, which may reduce its effectiveness in preventing pregnancy. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid or limit the use of alcohol during treatment with lomitapide, and seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Coadministration with weak inhibitors of CYP450 3A4 including oral contraceptives may increase the plasma concentrations of lomitapide, which is primarily metabolized by the isoenzyme. Weak CYP450 3A4 inhibitors increase lomitapide exposure by approximately 2-fold according to the product labeling.
MANAGEMENT: The maximum recommended dosage of lomitapide is 30 mg daily when used in combination with weak CYP450 3A4 inhibitors including oral contraceptives. Likewise, if oral contraceptives are initiated during treatment with lomitapide, the dosage of lomitapide may require adjustment. Patients should be advised that hormone absorption from oral contraceptives may be incomplete if vomiting or diarrhea occurs while taking lomitapide, which would warrant the use of additional contraceptive methods, especially since lomitapide may be teratogenic.
- "Product Information. Juxtapid (lomitapide)." Aegerion Pharmaceuticals Inc, Cambridge, MA.
Generic Name: lomitapide
Brand name: Juxtapid
Synonyms: Lomitapide
Generic Name: norethindrone
Brand name: Aygestin, Camila, Errin, Jolivette, Nora-Be, Ortho Micronor, Jolivette, Nor-QD, Nora-Be
Synonyms: Norethindrone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Juxtapid Capsules-Norethindrone Acetate
- Juxtapid Capsules-Norethindrone and Mestranol
- Juxtapid Capsules-Norethindrone Tablets
- Juxtapid Capsules-Norethindrone, ethinyl estradiol, and ferrous fumarate
- Juxtapid Capsules-Norflex
- Juxtapid Capsules-Norflex Injection
- Norethindrone (Hormone Replacement Therapy)-Jynarque