Juxtapid Capsules and Xanax

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

ALPRAZolam may increase the blood levels of lomitapide. You may be more likely to experience side effects such as diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, and liver damage. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Avoid or limit the use of alcohol to no more than one drink per day during treatment with lomitapide, and seek immediate medical attention if you develop signs and symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of lomitapide, which is primarily metabolized by the isoenzyme. Weak CYP450 3A4 inhibitors increase lomitapide exposure by approximately 2-fold according to the product labeling.

MANAGEMENT: The maximum recommended dosage of lomitapide is 30 mg daily when used in combination with weak CYP450 3A4 inhibitors such as alprazolam, amiodarone, amlodipine, atorvastatin, bicalutamide, cilostazol, cimetidine, cyclosporine, dasatinib, fluoxetine, fluvoxamine, ginkgo, goldenseal, isoniazid, ivacaftor, lapatinib, nilotinib, pazopanib, ranitidine, ranolazine, ticagrelor, tipranavir/ritonavir, and zileuton.

Juxtapid Capsules

Generic Name: lomitapide

Brand name: Juxtapid

Synonyms: Lomitapide

What is Juxtapid Capsules?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?