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Kadian and Mexitil

Determining the interaction of Kadian and Mexitil and the possibility of their joint administration.

Check result:

Kadian <> Mexitil

Relevance: 18.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using morphine together with mexiletine may decrease the effects of mexiletine. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Opioids may reduce the rate of absorption and onset of action of oral mexiletine. The mechanism is delayed gastric emptying by the opioid. Clinical data are limited. Plasma levels of mexiletine were decreased by 31% to 50% after 3 hours in patients who had also received diamorphine or morphine, compared to patients who did not receive opioids. Subtherapeutic mexiletine levels occurred in 47% of patients who received diamorphine and in 25% of patients who received morphine.

MANAGEMENT: Monitoring for altered efficacy is advisable.

References

Smyllie HC, Doar JW, Head CD, Leggett RJ "A trial of intravenous and oral mexiletine in acute myocardial infarction." Eur J Clin Pharmacol 26 (1984): 537-42
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Pottage A, Campbell RW, Achuff SC, Murray A, Julian DG, Prescott LF "The absorption of oral mexiletine in coronary care patients." Eur J Clin Pharmacol 13 (1978): 393-9

Kadian

Generic Name: morphine

Brand name: Kadian, Arymo ER, MorphaBond ER, Avinza, MS Contin, Duramorph PF, Infumorph, Mitigo, RMS, Roxanol

Synonyms: n.a.

What is Kadian?

Mexitil

Generic Name: mexiletine

Brand name: Mexitil

Synonyms: n.a.

What is Mexitil?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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