Kaletra and Levomilnacipran Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ritonavir may increase the blood levels and effects of levomilnacipran. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience increased side effects such as nausea, vomiting, constipation, rapid heartbeat, palpitation, erectile dysfunction (males), or any unusual symptoms. If you have high blood pressure, you may need closer monitoring of your blood pressure while you are receiving these medications. You should also avoid activities requiring mental alertness such as driving or operating machinery until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with potent inhibitors of CYP450 3A4 may increase the plasma concentrations of levomilnacipran, which is primarily metabolized by the isoenzyme. When coadministered with the potent CYP450 3A4 inhibitor, ketoconazole, levomilnacipran peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.4- and 1.6-fold, respectively, compared to administration alone.

MANAGEMENT: The dosage of levomilnacipran should not exceed 80 mg once daily when used with potent CYP450 3A4 inhibitors.

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

Levomilnacipran Hydrochloride

Generic Name: levomilnacipran

Brand name: Fetzima

Synonyms: Levomilnacipran

What is Levomilnacipran Hydrochloride?