Kaletra and Mektovi

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ritonavir may reduce the blood levels of binimetinib, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 1A2, P-glycoprotein (P-gp), and/or uridine diphosphate glucuronosyltransferase (UGT) 1A1 or 2B7 may decrease the plasma levels and therapeutic efficacy of binimetinib. The proposed mechanism involves enhanced metabolic clearance of binimetinib through induction of CYP450 1A2, P-gp, and/or UGT 1A1 or 2B7. The clinical significance of this interaction is unknown as no clinically relevant drug interactions have been demonstrated with binimetinib.

MANAGEMENT: Until further information is available, caution is recommended if binimetinib must be used concomitantly with CYP450 1A2, P-gp, and/or UGT 1A1 or 2B7 inducers. Pharmacologic response to binimetinib should be monitored more closely whenever a CYP450 1A2, P-gp, and/or UGT 1A1 or 2B7 inducer is added to or withdrawn from therapy, and the binimetinib dosage adjusted as necessary.

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

Mektovi

Generic Name: binimetinib

Brand name: Mektovi

Synonyms: n.a.

What is Mektovi?