Kaletra and Miconazole Buccal mucosa

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

The coadministration with fluconazole may slightly increase the plasma concentrations of ritonavir. The proposed mechanism is fluconazole inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of ritonavir. In an open-label, randomized, crossover study consisting of eight healthy subjects, fluconazole (400 mg on day 1, 200 mg on days 2 to 5) increased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ritonavir (200 mg every 6 hours for 4 days) by approximately 15% and 12%, respectively, compared to when ritonavir was administered alone. In a study of 3 HIV-infected patients treated with ritonavir 600 mg orally twice a day, there were no detectable changes in the pharmacokinetics of ritonavir following addition of fluconazole. Other azole antifungal agents are expected to affect ritonavir in a similar fashion but possibly to a greater extent, since fluconazole is a relatively weak inhibitor of CYP450 3A4. No special precautions are necessary when fluconazole is given with ritonavir.

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

Miconazole Buccal mucosa

Generic Name: miconazole

Brand name: Oravig, Monistat IV, Oravig

Synonyms: Miconazole oral (buccal), Miconazole (Oral)

What is Miconazole Buccal mucosa?