Kaletra and Mifeprex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using miFEPRIStone together with ritonavir. Combining these medications may significantly increase the blood levels and effects of miFEPRIStone. This may increase the risk and/or severity of side effects, particularly if you are on this medication for a prolonged period. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of mifepristone, which is primarily metabolized by the isoenzyme. The clinical impact of this interaction has not been studied.

MANAGEMENT: Due to its potent antiglucocorticoid effects and potential to cause dose-related prolongation of the QT interval, extreme caution is advised when mifepristone is prescribed in combination with strong CYP450 3A4 inhibitors such as, but not limited to, itraconazole, ketoconazole, posaconazole, voriconazole, clarithromycin, conivaptan, delavirdine, nefazodone, telithromycin, and protease inhibitors. When used daily to control hyperglycemia secondary to hypercortisolism in patients with endogenous Cushing's syndrome, the dosage of mifepristone should be limited to 300 mg/day and used only when necessary.

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

Mifeprex

Generic Name: mifepristone

Brand name: Mifeprex, Korlym

Synonyms: n.a.

What is Mifeprex?