Kaletra and Proleukin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ritonavir together with aldesleukin may increase the effects of ritonavir. Contact your doctor if you experience fever, sore throat, headache, increased urination or extreme thirst, easy bruising or bleeding, signs of a new infection, such as fever or chills, cough, or flu symptoms, nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), and others. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The use of aldesleukin may increase blood levels of some protease inhibitors by inhibiting their metabolism via the CYP450 3A4 pathway. Indinavir AUCs increased by 26% to 214% in 8 of 9 patients receiving concomitant therapy.

MANAGEMENT: Monitoring for signs and symptoms of protease inhibitor toxicity (e.g., hyperbilirubinemia, nausea, vomiting, diarrhea, flank pain, nephrolithiasis, urolithiasis) is recommended when aldesleukin is added or the dosage increased.

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

Proleukin

Generic Name: aldesleukin

Brand name: Proleukin

Synonyms: n.a.

What is Proleukin?