Kaletra and Raltegravir Chewable Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with ritonavir may decrease the plasma concentrations of raltegravir. The proposed mechanism is ritonavir induction of the glucuronidation of raltegravir via UGT1A1. When a single 400 mg dose of raltegravir was administered to ten study subjects in combination with ritonavir 100 mg every 12 hours for 16 days, raltegravir peak plasma concentration (Cmax), systemic exposure (AUC) and trough plasma concentration (Cmin) decreased by 24%, 16% and 1%, respectively. The effects of ritonavir given at a dosage greater than 100 mg twice daily have not been evaluated.

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

Raltegravir Chewable Tablets

Generic Name: raltegravir

Brand name: Isentress, Isentress HD

Synonyms: Raltegravir

What is Raltegravir Chewable Tablets?