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Kaletra and Tipranavir Oral Solution

Determining the interaction of Kaletra and Tipranavir Oral Solution and the possibility of their joint administration.

Check result:
Kaletra <> Tipranavir Oral Solution
Relevance: 06.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ritonavir and tipranavir can cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Coadministration of tipranavir with ritonavir 200 mg has been associated with cases of clinical hepatitis and hepatic decompensation including some fatalities.

MANAGEMENT: Close monitoring of hepatic function is recommended in patients treated with tipranavir and ritonavir. Particular caution is warranted in patients with chronic hepatitis B or C coinfection, as they may have an increased risk of hepatotoxicity. Patients should be advised to notify their physician if they experience signs and symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice.

References
  • "Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

Tipranavir Oral Solution

Generic Name: tipranavir

Brand name: Aptivus

Synonyms: Tipranavir

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction