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Kaletra and Ulipristal Tablets (Ella)

Determining the interaction of Kaletra and Ulipristal Tablets (Ella) and the possibility of their joint administration.

Check result:
Kaletra <> Ulipristal Tablets (Ella)
Relevance: 06.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ritonavir may decrease the blood levels and effects of ulipristal. If you are currently taking or have taken ritonavir within the past 2 to 3 weeks, the effectiveness of ulipristal in preventing pregnancy may be reduced. You should discuss your contraceptive options with your healthcare provider. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The concomitant use of CYP450 3A4 inducers may decrease the plasma concentrations and efficacy of ulipristal, which is primarily metabolized by the isoenzyme. Induction of CYP450 3A4 may last for up to 4 weeks after discontinuation of the enzyme inducer.

MANAGEMENT: Concomitant use of ulipristal with CYP450 3A4 inducers should be avoided if possible and nonhormonal emergency contraception should be considered.

References
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  • "Product Information. ella (ulipristal)." Afaxys Inc., Charleston, SC.
Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

Ulipristal Tablets (Ella)

Generic Name: ulipristal

Brand name: Ella, Ella

Synonyms: Ulipristal

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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