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Kaletra and Zaleplon

Determining the interaction of Kaletra and Zaleplon and the possibility of their joint administration.

Check result:
Kaletra <> Zaleplon
Relevance: 06.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Inducers of hepatic microsomal enzyme CYP450 3A4 may increase the plasma clearance of zaleplon, which is partially metabolized by this enzyme. Be aware of the possibility of reduced efficacy associated with zaleplon if these drugs are given together.

References
  • "Product Information. Sonata (zaleplon)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

Zaleplon

Generic Name: zaleplon

Brand name: Sonata

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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