Kaletra and Zidovudine oral/injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration of ritonavir (300 mg every six hours) has been reported to decrease the area under the plasma concentration-time curve of zidovudine (200 mg every eight hours) by 25%. The plasma level of ritonavir has been reported not to have been affected. The mechanism of this interaction may be related to the induction of hepatic glucuronosyltransferase activities by ritonavir, which may enhance the glucuronidation of zidovudine. Adjustments in zidovudine dosage are unlikely to be necessary.

Kaletra

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: n.a.

What is Kaletra?

Zidovudine oral/injection

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine oral/injection?