Kaletra Oral Solution and Norpramin
Determining the interaction of Kaletra Oral Solution and Norpramin and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using desipramine together with ritonavir may increase the effects of desipramine. Contact your doctor if you experience uneven heartbeats, extreme drowsiness, vomiting, blurred vision, dry mouth, confusion, hallucinations, muscle stiffness, feeling hot or cold, constipation, and urinary retention. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Coadministration with ritonavir may increase the plasma concentrations of desipramine. The mechanism is ritonavir inhibition of CYP450 2D6, the isoenzyme responsible for the metabolic clearance of desipramine. In an open label study consisting of 14 healthy volunteers, ritonavir (500 mg orally every 12 hours) increased the mean area under the plasma concentration-time curve (AUC) and half-life of desipramine (100 mg single dose) by approximately 145% and 100%, respectively. It is not known to what extent, if any, the interaction may occur when ritonavir is used in lower dosages as a pharmacokinetic booster. No interaction was observed when desipramine was given with lopinavir-ritonavir in drug interaction studies.
MANAGEMENT: A reduction in desipramine dosage should be considered in patients treated with antiretroviral dosages of ritonavir. In patients stabilized on desipramine, clinical and laboratory monitoring of antidepressant response is recommended whenever ritonavir is added to or withdrawn from therapy, and the dosage adjusted accordingly. Patients should be advised to notify their physician if they experience excessive tricyclic antidepressant effects such as dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or orthostatic hypotension.
- Bertz RJ, Cao G, Cavanaugh JH, Hsu A, Granneman GR, Leonard JM "Effect of ritonavir on the pharmacokinetics of desipramine." Int Conf AIDS 11 (1996): 89(ab.no.mo.b.1201)
- "Product Information. Kaletra (lopinavir-ritonavir)" Abbott Pharmaceutical, Abbott Park, IL.
- "Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Generic Name: lopinavir / ritonavir
Brand name: Kaletra
Synonyms: Kaletra
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Kaletra Oral Solution-Northera
- Kaletra Oral Solution-Nortrel 1/35
- Kaletra Oral Solution-Nortrel 7/7/7
- Kaletra Oral Solution-Nortriptyline
- Kaletra Oral Solution-Nortriptyline Capsules
- Kaletra Oral Solution-Nortriptyline Hydrochloride
- Norpramin-Kalexate
- Norpramin-Kalexate Powder
- Norpramin-Kalliga
- Norpramin-Kalosar
- Norpramin-Kalydeco
- Norpramin-Kalydeco (Ivacaftor Granules)