Kaletra Oral Solution and Rapiflux

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using FLUoxetine together with ritonavir may alter the effects of both medications. Contact your doctor if you experience nausea, vomiting, fever, sleepiness, rapid or uneven heartbeat, confusion, fainting, or if your condition worsens. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Fluoxetine may raise the plasma concentration of ritonavir by inhibiting its metabolism. A 19% increase has been observed in the mean area under the plasma concentration-time curve of ritonavir. One pharmacokinetic study concluded that no ritonavir dose adjustment was necessary. Also, ritonavir appears to be a moderately competitive inhibitor of the enzyme CYP450 2D6. Elevated serum fluoxetine levels are therefore possible.

MANAGEMENT: If fluoxetine and ritonavir must be used concurrently, the patient should be monitored for fluoxetine toxicity (nausea, vomiting, dizziness, confusion, vertigo, tremor, and gait abnormalities). A reduction in fluoxetine dosage may be necessary.

Kaletra Oral Solution

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Kaletra

What is Kaletra Oral Solution?

Rapiflux

Generic Name: fluoxetine

Brand name: Prozac, Prozac Weekly, PROzac Pulvules, Sarafem, Rapiflux, Selfemra

Synonyms: Rapiflux (Oral)

What is Rapiflux?