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Kaletra Oral Solution and Theochron

Determining the interaction of Kaletra Oral Solution and Theochron and the possibility of their joint administration.

Check result:

Kaletra Oral Solution <> Theochron

Relevance: 05.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ritonavir together with theophylline may decrease the effects of theophylline. Contact your doctor if your condition changes or if you experience breathing difficulties. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The coadministration with ritonavir may decrease the plasma concentrations of theophylline. The proposed mechanism is ritonavir induction of CYP450 1A2, the isoenzyme responsible for the metabolic clearance of theophylline. In a study involving 27 subjects, ritonavir (500 mg orally every 12 hours for 10 days) decreased the steady-state peak plasma concentration (Cmax), area under the concentration-time curve (AUC), and trough concentration (Cmin) of theophylline (3 mg/kg every 8 hours) by 32%, 43%, and 57%, respectively, compared to placebo. The half-life also decreased from 8.4 hours at baseline to 3.6 hours after 10 days of ritonavir.

MANAGEMENT: During coadministration with ritonavir, the possibility of a diminished therapeutic response to theophylline should be considered. Dosage adjustment as well as clinical and laboratory monitoring may be appropriate whenever ritonavir is added to or withdrawn from therapy.

References

"Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
Hsu A, Granneman GR, Witt G, Cavanaugh JH, Leonard J "Assessment of multiple doses of ritonavir on the pharmacokinetics of theophylline." Int Conf AIDS 11 (1996): 89(ab.no.mo.b.1200)

Kaletra Oral Solution

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Kaletra

What is Kaletra Oral Solution?

Theochron

Generic Name: theophylline

Brand name: Theochron, Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: n.a.

What is Theochron?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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