Kaletra Oral Solution and Vardenafil Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using vardenafil together with ritonavir. Combining these medications may significantly increase the blood levels and effects of vardenafil. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision or hearing loss, chest pain or tightness, irregular heartbeat, and/or priapism (prolonged and painful erection unrelated to sexual activity), as these may be signs and symptoms of excessive vardenafil levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with ritonavir may significantly increase the plasma concentrations of vardenafil. The mechanism is ritonavir inhibition of CYP450 3A4, the isoenzyme partially responsible for the metabolic clearance of vardenafil. According to the product labeling, coadministration of vardenafil 5 mg in combination with ritonavir 600 mg twice a day resulted in a 13-fold increase in vardenafil peak plasma concentration (Cmax) and 49-fold increase systemic exposure (AUC). The half-life of vardenafil, normally 4 to 5 hours, was significantly prolonged to 26 hours. Ritonavir Cmax and AUC were reduced by approximately 20%.

MANAGEMENT: Patients treated with ritonavir should not receive more than a single 2.5 mg dose of vardenafil within a 72-hour period. Patients should be advised to promptly notify their physician if they experience pain or tightness in the chest or jaw, irregular heartbeat, nausea, shortness of breath, visual disturbances, syncope, or prolonged erection (greater than 4 hours).

Kaletra Oral Solution

Generic Name: lopinavir / ritonavir

Brand name: Kaletra

Synonyms: Kaletra

What is Kaletra Oral Solution?

Vardenafil Tablets

Generic Name: vardenafil

Brand name: Levitra, Staxyn

Synonyms: Vardenafil

What is Vardenafil Tablets?