Kalydeco (Ivacaftor Granules) and Ropivacaine Hydrochloride

• Generic Name: ivacaftor
• Dosage Forms: tablet, film coated; oral granule
• Other Brand Names: Kalydeco

• It is used to treat cystic fibrosis.

• Generic Name: ropivacaine
• Dosage Forms: n.a.
• Other Brand Names: Naropin, Naropin Polyamp, Naropin SDV, Naropin Novaplus

Local or regional anesthesia for surgery (including cesarean section) and management of acute pain (e.g., postoperative pain, labor pain).

Used as a component of multimodal analgesia (i.e., simultaneous use of a combination of analgesic drugs and techniques that target different mechanisms) in the management of postoperative pain.

Compared with bupivacaine, generally has a similar onset and duration of sensory block, but a lower intensity and shorter duration of motor block. Appears to have a lower potential for CNS and cardiovascular toxicity than bupivacaine.

Not recommended for obstetrical paracervical block, retrobulbar block for ophthalmic surgery, spinal anesthesia (subarachnoid block), or IV regional anesthesia (Bier block) because of lack of clinical experience and/or risk of toxicity.