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Kanamycin and Xatmep

Determining the interaction of Kanamycin and Xatmep and the possibility of their joint administration.

Check result:

Kanamycin <> Xatmep

Relevance: 26.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using kanamycin together with methotrexate may decrease the effects of methotrexate. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of an oral aminoglycoside and methotrexate may lead to decreased gastrointestinal absorption of methotrexate which could result in reduced efficacy of methotrexate. The proposed mechanism is a malabsorption syndrome caused by oral aminoglycosides. It has been suggested that increased absorption could occur with kanamycin.

MANAGEMENT: Patients should be closely monitored for altered efficacy and safety of methotrexate. Consider the intravenous route of administration for methotrexate to avoid the interaction.

References

Cohen MH, Creaven PJ, Fossieck BE, Johnston AV, Williams CL "Effect of oral prophylactic broad spectrum nonabsorbable antibiotics on the gastrointestinal absorption of nutrients and methotrexate in small cell bronchogenic carcinoma patients." Cancer 38 (1976): 1556-9
Shen DD, Azarnoff DL "Clinical pharmacokinetics of methotrexate." Clin Pharmacokinet 3 (1978): 1-13
Keusch GT, Troncale FJ, Buchanan RD "Malabsorption due to paromomycin." Arch Intern Med 125 (1970): 273-6

Kanamycin

Generic Name: kanamycin

Brand name:

Synonyms: Kanamycin (Injection)

What is Kanamycin?

Xatmep

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: n.a.

What is Xatmep?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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