Kapspargo Sprinkle and Pretomanid Tablets

• Generic Name: metoprolol
• Dosage Forms: capsule, extended release
• Other Brand Names: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

• It is used to treat high blood pressure.
• It is used to treat chest pain or pressure.
• It is used to treat heart failure (weak heart).
• It may be given to you for other reasons. Talk with the doctor.

• Generic Name: pretomanid
• Dosage Forms: tablet
• Other Brand Names:

Limited Population: Pretomanid is an antimycobacterial indicated as part of a combination regimen with bedaquiline and linezolid for the treatment of adults with pulmonary extensively drug resistant (XDR), treatment-intolerant or nonresponsive multidrug-resistant (MDR) tuberculosis (TB). Approval of this indication is based on limited clinical safety and efficacy data. This drug is indicated for use in a limited and specific population of patients.

Pretomanid is not indicated for patients with: drug-sensitive (DS) tuberculosis, latent infection due to Mycobacterium tuberculosis, extrapulmonary infection due to M. tuberculosis, or MDR-TB that is not treatment-intolerant or nonresponsive to standard therapy.

Safety and effectiveness of pretomanid have not been established for its use in combination with drugs other than bedaquiline and linezolid as part of the recommended dosing regimen.