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Kenalog-40 and Rifadin

Determining the interaction of Kenalog-40 and Rifadin and the possibility of their joint administration.

Check result:

Kenalog-40 <> Rifadin

Relevance: 08.01.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using rifAMPin together with triamcinolone may decrease the effects of triamcinolone. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifampin may induce the hepatic metabolism of corticosteroids, possibly reducing their therapeutic effect. The elimination half-life of corticosteroids has been shown to be reduced by up to 45% when rifampin is coadministered. Theoretically, rifabutin could interact with corticosteroids in a similar manner.

MANAGEMENT: Patients should be monitored for altered corticosteroid effects. Dosage increases may be necessary. Two- to threefold increases in prednisolone dosage have been recommended.

References

Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Lee KH, Shin JG, Chong WS, Kim S, Lee JS, Jang IJ, Shin SG "Time course of the changes in prednisolone pharmacokinetics after co-administration or discontinuation of rifampin." Eur J Clin Pharmacol 45 (1993): 287-9
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
Kyriazopoulou V, Parparousi O, Vagenakis AG "Rifampicin-induced adrenal crisis in Addisonian patients receiving corticosteroid replacement therapy." J Clin Endocrinol Metab 59 (1984): 1204-6
Powell-Jackson PR, Gray BJ, Heaton RW, et al "Adverse effect of rifampicin administration on steroid-dependent asthma." Am Rev Respir Dis 128 (1983): 307-10
McAllister WA, Thompson PJ, Al-Habet SM, Rogers HJ "Rifampicin reduces effectiveness and bioavailability of prednisolone." Br Med J 286 (1983): 923-5
Bergrem H, Refvem OK "Altered prednisolone pharmacokinetics in patients treated with rifampicin." Acta Med Scand 213 (1983): 339-43

Kenalog-40

Generic Name: triamcinolone

Brand name: Kenalog-40, Zilretta, Aristocort, Azmacort

Synonyms: Kenalog-40 (injection)

What is Kenalog-40?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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