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Kengreal and Prasugrel Tablets

Determining the interaction of Kengreal and Prasugrel Tablets and the possibility of their joint administration.

Check result:

Kengreal <> Prasugrel Tablets

Relevance: 26.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cangrelor may block the action of prasugrel and reduce its effectiveness when they are given at the same time. To minimize the interaction, prasugrel should be given after cangrelor infusion is complete. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The antiplatelet effect of clopidogrel or prasugrel may be inhibited when they are administered at the same time as cangrelor. The mechanism is competitive inhibition of P2Y12 platelet receptors by cangrelor, which, unlike clopidogrel or prasugrel, binds reversibly at the receptor site and causes a temporary rather than persistent inhibition of ADP-induced platelet activation and aggregation. According to the product labeling for cangrelor, the expected antiplatelet effect of a 600 mg loading dose of clopidogrel or a 60 mg loading dose of prasugrel was blocked when these agents were administered during a cangrelor infusion. Conversely, pretreatment with clopidogrel or prasugrel does not impair the antiplatelet effect of cangrelor, but may result in additive platelet inhibition.

MANAGEMENT: To maintain platelet inhibition, clopidogrel 600 mg or prasugrel 60 mg should be administered immediately after discontinuation of the cangrelor infusion. Do not administer prior to discontinuation of cangrelor, as clopidogrel and prasugrel will have no antiplatelet effect until the next dose is administered. Alternatively, ticagrelor 180 mg may be administered at any time during cangrelor infusion or immediately after discontinuation.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Kengreal (cangrelor)." The Medicines Company, Parsippany, NJ.
Dovlatova NL, Jakubowski JA, Sugidachi A, Heptinstall S "The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function." J Thromb Haemost 6 (2008): 1153-9

Kengreal

Generic Name: cangrelor

Brand name: Kengreal

Synonyms: n.a.

What is Kengreal?

Prasugrel Tablets

Generic Name: prasugrel

Brand name: Effient

Synonyms: Prasugrel

What is Prasugrel Tablets?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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