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Keppra XR and Otrexup

Determining the interaction of Keppra XR and Otrexup and the possibility of their joint administration.

Check result:

Keppra XR <> Otrexup

Relevance: 16.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with levetiracetam may increase plasma concentrations of methotrexate. Neither the mechanism of interaction nor the clinical significance have been established. Plasma levels of methotrexate should be carefully monitored in patients receiving this combination.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Methotrexate and Methotrexate LPF (methotrexate)." Lederle Laboratories, Wayne, NJ.
Cerner Multum, Inc. "Australian Product Information." O 0

Keppra XR

Generic Name: levetiracetam

Brand name: Keppra, Keppra XR, Roweepra, Spritam, Roweepra XR

Synonyms: Keppra-XR

What is Keppra XR?

Otrexup

Generic Name: methotrexate

Brand name: Methotrexate Sodium, Preservative Free, Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep

Synonyms: Otrexup (injection)

What is Otrexup?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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