Ketek and Metoprolol Tartrate Tablet

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using metoprolol together with telithromycin can lower your blood pressure or cause mental status changes. Low blood pressure can cause dizziness or feeling like you might pass out, especially when getting up from a sitting or lying position. Talk with your doctor before using metoprolol and telithromycin together. You may need a dose adjustment or need your blood pressure checked more often if you take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with telithromycin may increase the plasma concentrations of metoprolol. The proposed mechanism is telithromycin inhibition of CYP450 2D6, the isoenzyme responsible for the metabolic clearance of metoprolol. Coadministration of telithromycin and metoprolol has resulted in an increase of approximately 38% in the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of metoprolol, with no change in the elimination half-life. Single-dose metoprolol had no significant effect on the AUC of telithromycin.

MANAGEMENT: In patients treated with metoprolol for heart failure, the increased exposure to metoprolol may be of clinical importance, thus coadministration with telithromycin should be considered with caution. Excessive beta blockade may worsen heart failure in patients who have dependency to sympathetic stimulation in maintaining hemodynamic function.

Ketek

Generic Name: telithromycin

Brand name: Ketek

Synonyms: n.a.

What is Ketek?

Metoprolol Tartrate Tablet

Generic Name: metoprolol

Brand name: Kapspargo Sprinkle, Lopressor, Toprol-XL, Toprol XL

Synonyms: Metoprolol

What is Metoprolol Tartrate Tablet?