Ketek and Prandin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using telithromycin together with repaglinide can increase the effects of repaglinide. You should be advised to regularly monitor your blood sugar and counseled on how to recognize and treat hypoglycemia (low blood sugar), which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations. You may need a dose adjustment or blood sugar checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with telithromycin may increase the plasma concentrations of repaglinide. The proposed mechanism is telithromycin inhibition of repaglinide metabolism via CYP450 3A4 in the intestine and liver. In 12 healthy, nonsmoking volunteers, pretreatment with telithromycin (800 mg orally once a day for 3 days) increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of repaglinide (0.25 mg single oral dose) by 38% and 77%, respectively, compared to placebo. Telithromycin also increased the urinary excretion of unchanged repaglinide by 129% but had no effect on its elimination half-life. Compared with the placebo phase, telithromycin reduced the maximum blood glucose concentration by 0.7 mmol/L and mean blood glucose concentration from 0 to 3 hours by 0.5 mmol/L. However, no subject developed symptomatic hypoglycemia as a result of the interaction. The lack of clinical adverse effects may be explained, at least partially, by frequent carbohydrate intake during the study and the use of a subtherapeutic dose of repaglinide.

MANAGEMENT: Because the antidiabetic effect of repaglinide is dose- and concentration-dependent, pharmacologic response to repaglinide should be monitored more closely whenever telithromycin is added to or withdrawn from therapy. Patients should be advised to regularly monitor their blood sugar and counseled on how to recognize and treat hypoglycemia, which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations. The repaglinide dosage may require adjustment if an interaction is suspected.

Ketek

Generic Name: telithromycin

Brand name: Ketek

Synonyms: n.a.

What is Ketek?

Prandin

Generic Name: repaglinide

Brand name: Prandin

Synonyms: n.a.

What is Prandin?