Ketoconazole (Systemic) and Nelfinavir Oral Powder
Determining the interaction of Ketoconazole (Systemic) and Nelfinavir Oral Powder and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:One study has reported that when ketoconazole was administered concomitantly with nelfinavir, the half-life of nelfinavir increased from 2.92 hours to 5.09 hours, the clearance decreased from 28.5 L/hour to 20.0 L/hour, and the volume of distribution increased from 120 L to 147 L. The mechanism is believed to be the inhibition of CYP450 3A enzymes by ketoconazole. No specific action is recommended. However, the clinician should be aware of the potential for this interaction.
- Kerr BM, Yuen GJ, Sandoval T, Wu E, Shetty BV, Anderson R "The pharmacokinetics of nelfinavir administered alone and with ketoconazole in healthy volunteers." Clin Pharmacol Ther 61 (1997): 147(ab.no.pi-42)
Generic Name: ketoconazole
Brand name: Nizoral
Synonyms: Ketoconazole
Generic Name: nelfinavir
Brand name: Viracept
Synonyms: Nelfinavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ketoconazole (Systemic)-Nelfinavir Tablets
- Ketoconazole (Systemic)-Nembutal
- Ketoconazole (Systemic)-Nembutal Sodium injection
- Ketoconazole (Systemic)-Neo DM
- Ketoconazole (Systemic)-Neo-Fradin
- Ketoconazole (Systemic)-Neo-Metric
- Nelfinavir Oral Powder-Ketoconazole and Hydrocortisone
- Nelfinavir Oral Powder-Ketoconazole Tablets
- Nelfinavir Oral Powder-Ketoprofen
- Nelfinavir Oral Powder-Ketoprofen Capsules
- Nelfinavir Oral Powder-Ketoprofen Extended-Release Capsules
- Nelfinavir Oral Powder-Ketorolac