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Ketoconazole (Systemic) and Sodium Bicarbonate Infant Injection

Determining the interaction of Ketoconazole (Systemic) and Sodium Bicarbonate Infant Injection and the possibility of their joint administration.

Check result:

Ketoconazole (Systemic) <> Sodium Bicarbonate Infant Injection

Relevance: 10.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ketoconazole together with sodium bicarbonate can decrease the effects of ketoconazole. Talk with your doctor before using ketoconazole while you are using sodium bicarbonate. Separation of doses by two or more hours is recommended. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The dissolution of oral ketoconazole requires an acidic environment. Medications that decrease the acidity of the stomach, such as omeprazole or H2 antagonists can reduce the bioavailability of ketoconazole by 75% to 80%. Antacids are also expected to impair ketoconazole absorption.

MANAGEMENT: It is recommended to administer antacids at least 1 hour before or 2 hours after ketoconazole. Patients should be monitored for altered antifungal effects and the ketoconazole dosage adjusted if necessary.

References

Chin TWF, Loeb M, Fong IW "Effects of an acidic beverage (coca-cola) on absorption of ketoconazole." Antimicrob Agents Chemother 39 (1995): 1671-5
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Van der Meer JW, Keuning JJ "The influence of gastric acidity on the bio-availability of ketoconazole." J Antimicrob Chemother 6 (1980): 552-4
Cerner Multum, Inc. "Canadian Product Information." O 0 (2015):
Cerner Multum, Inc "ANVISA Bulário Eletrônico. Available from: URL: http://www.anvisa.gov.br/datavisa/fila_bula/index.asp." O 0 (2015):
Brass C, Galgiani JN, Blaschke TF, et al "Disposition of ketoconazole, an oral antifungal, in humans." Antimicrob Agents Chemother 21 (1982): 151-8
Carlson JA, Mann HJ, Canafax DM "Effect of pH on disintegration and dissolution of ketoconazole tablets." Am J Hosp Pharm 40 (1983): 1334-6
"Product Information. Ketoconazole (ketoconazole)." Mylan Pharmaceuticals Inc, Morgantown, WV.

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?

Sodium Bicarbonate Infant Injection

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Sodium bicarbonate, Sodium Bicarbonate

What is Sodium Bicarbonate Infant Injection?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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