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Ketoconazole (Systemic) and Sucralfate Oral Suspension

Determining the interaction of Ketoconazole (Systemic) and Sucralfate Oral Suspension and the possibility of their joint administration.

Check result:

Ketoconazole (Systemic) <> Sucralfate Oral Suspension

Relevance: 10.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Sucralfate may bind with ketoconazole in the stomach and decrease ketoconazole absorption by up to 20%. Patients should be advised to take ketoconazole at least 2 hours before or 6 hours after sucralfate and their clinical response should be monitored.

References

Hoeschele JD, Roy AK, Pecoraro VL, Carver PL "In vitro analysis of the interaction between sucralfate and ketoconazole." Antimicrob Agents Chemother 38 (1994): 319-25
Carver PL, Berardi RR, Knapp MJ, Rider JM, Kauffman CA, Bradley SF, Atassi M "In vivo interaction of ketoconazole and sucralfate in healthy volunteers." Antimicrob Agents Chemother 38 (1994): 326-9
Piscitelli SC, Goss TF, Wilton JH, D'Andrea DT, Goldstein H, Schentag JJ "Effects of ranitidine and sucralfate on ketoconazole bioavailability." Antimicrob Agents Chemother 35 (1991): 1765-71

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?

Sucralfate Oral Suspension

Generic Name: sucralfate

Brand name: Carafate

Synonyms: Sucralfate

What is Sucralfate Oral Suspension?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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