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Ketoconazole (Systemic) and Sustol injection

Determining the interaction of Ketoconazole (Systemic) and Sustol injection and the possibility of their joint administration.

Check result:
Ketoconazole (Systemic) <> Sustol injection
Relevance: 10.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In vitro human hepatic microsomal studies indicate that ketoconazole inhibits ring oxidation of granisetron. However, the clinical significance in vivo is unknown, particularly given the wide margin of safety of granisetron.

References
  • "Product Information. Kytril (granisetron)." SmithKline Beecham, Philadelphia, PA.
Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

Sustol injection

Generic Name: granisetron

Brand name: Sustol, Kytril, Sancuso

Synonyms: Sustol (injection), Sustol Injection

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle