Drug search by name

Ketoconazole (Systemic) and Topcare Allergy Relief

Determining the interaction of Ketoconazole (Systemic) and Topcare Allergy Relief and the possibility of their joint administration.

Check result:

Ketoconazole (Systemic) <> Topcare Allergy Relief

Relevance: 10.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Ketoconazole has been reported to inhibit the metabolism of loratadine. Area under the plasma concentration time curve (AUC) has increased 180% for loratadine and 56% for its active metabolite. The mechanism of this interaction is inhibition of CYP450 3A4 metabolism by ketoconazole. No adverse effects or cardiotoxicity were observed in this study. Loratadine and cetirizine appear to be safe for use with ketoconazole. Terfenadine and astemizole should not be used with ketoconazole.

References

Woosley R, Carrow WR "Analysis of potential adverse drug reactions--a case of mistaken identity." Am J Cardiol 74 (1994): 208-9
"Product Information. Nizoral (ketoconazole)." Janssen Pharmaceutica, Titusville, NJ.
Yumibe N, Huie K, Chen KJ, Clement RP, Cayen MN "Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine." Int Arch Allery Immunol 207 (1995): 420
"Product Information. Claritin (loratadine)." Schering Laboratories, Kenilworth, NJ.

Ketoconazole (Systemic)

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: Ketoconazole

What is Ketoconazole (Systemic)?

Topcare Allergy Relief

Generic Name: loratadine

Brand name: Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetapp ND, Ohm Allergy Relief, QlearQuil All Day & Night, Tavist ND, Wal-itin

Synonyms: Allergy Relief Tablets

What is Topcare Allergy Relief?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions