Ketoprofen Extended-Release Capsules and Major Heartburn Relief Maximum Strength
Determining the interaction of Ketoprofen Extended-Release Capsules and Major Heartburn Relief Maximum Strength and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:H2 antagonists may alter the disposition of nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in increased or decreased plasma concentrations. Data are varied, even for the same NSAID. The mechanism may be related to inhibition of metabolism, changes in gastric pH that decrease absorption, and/or reduced urinary elimination. Statistically significant changes have been small and of limited clinical significance. Clinical monitoring of patient response and tolerance is recommended.
- Scavone JM, Greenblatt DJ, Matlis R, Harmatz JS "Interaction of oxaprozin with acetaminophen, cimetidine, and ranitidine." Eur J Clin Pharmacol 31 (1986): 371-4
- Said SA, Foda AM "Influence of cimetidine on the pharmacokinetics of piroxicam in rat and man." Arzneimittelforschung 39 (1989): 790-2
- "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
Generic Name: ketoprofen
Brand name: Oruvail, Orudis, Actron, Orudis KT
Synonyms: Ketoprofen
Generic Name: famotidine
Brand name: Pepcid, Heartburn Relief, Pepcid AC, Pepcid AC Maximum Strength, Pepcid AC Chewable Tablets, Pepcid Oral Suspension
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ketoprofen Extended-Release Capsules-Makena
- Ketoprofen Extended-Release Capsules-Makena Auto-Injector
- Ketoprofen Extended-Release Capsules-Malarone
- Ketoprofen Extended-Release Capsules-Malarone Pediatric
- Ketoprofen Extended-Release Capsules-Mandelamine
- Ketoprofen Extended-Release Capsules-Mandelay
- Major Heartburn Relief Maximum Strength-Ketorolac
- Major Heartburn Relief Maximum Strength-Ketorolac (Systemic)
- Major Heartburn Relief Maximum Strength-Ketorolac Eye Drops (Multi-Dose Containers)
- Major Heartburn Relief Maximum Strength-Ketorolac Eye Drops (Single-Dose Containers)
- Major Heartburn Relief Maximum Strength-Ketorolac Injection
- Major Heartburn Relief Maximum Strength-Ketorolac nasal