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Khedezla and Tagamet

Determining the interaction of Khedezla and Tagamet and the possibility of their joint administration.

Check result:

Khedezla <> Tagamet

Relevance: 10.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Coadministration with cimetidine may increase the plasma concentrations of venlafaxine but not O-desmethylvenlafaxine (ODV), its pharmacologically active metabolite. The mechanism is inhibition of hepatic first-pass metabolism of venlafaxine by cimetidine. In an open-label, crossover study consisting of 18 healthy subjects, cimetidine (800 mg orally once a day for 5 days) increased the average steady-state concentrations of venlafaxine (50 mg orally three times a day) by 61% and decreased its apparent oral clearance by 43%, with significant interpatient variability. No changes were reported in the pharmacokinetics of ODV. Because ODV is present in the circulation at much greater concentrations than those of the parent drug, the overall pharmacologic activity is expected to increase only slightly during coadministration with cimetidine. Dosage reductions should not be necessary for most patients. However, for patients with preexisting hypertension, elderly patients, and patients with hepatic dysfunction, the interaction has not been studied and may be more pronounced.

References

Troy SM, Rudolph R, Mayersohn M, Chiang ST "The influence of cimetidine on the disposition kinetics of the antidepressant venlafaxine." J Clin Pharmacol 38 (1998): 467-74
"Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Khedezla

Generic Name: desvenlafaxine

Brand name: Khedezla, Pristiq

Synonyms: n.a.

What is Khedezla?

Tagamet

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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