Kisqali (400 MG Dose) and Nevirapine Extended-Release Tablets
Determining the interaction of Kisqali (400 MG Dose) and Nevirapine Extended-Release Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Nevirapine may reduce the blood levels of ribociclib. In some cases, this may make the medication less effective in treating your cancer. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of ribociclib, which is a substrate of the isoenzyme. Physiologically-based pharmacokinetic simulations (PBPK) suggest that a moderate CYP450 3A4 inducer, efavirenz, may decrease ribociclib Cmax and AUC by 37% and 60%, respectively. However, data with less potent CYP450 3A4 inducers are limited.
MANAGEMENT: The potential for diminished therapeutic effects of ribociclib should be considered when prescribed with inducers of CYP450 3A4, particularly moderate inducers including efavirenz and nevirapine. Pharmacologic effects of ribociclib should be monitored more closely whenever an inducer is added to or withdrawn from therapy. Alternative treatment may be required if an interaction is suspected.
- "Product Information. Kisqali (ribociclib)." Novartis Pharmaceuticals, East Hanover, NJ.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: ribociclib
Brand name: Kisqali
Synonyms: Kisqali
Generic Name: nevirapine
Brand name: Viramune, Viramune XR
Synonyms: Nevirapine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Kisqali (400 MG Dose)-Nevirapine Oral Suspension
- Kisqali (400 MG Dose)-Nevirapine Suspension
- Kisqali (400 MG Dose)-Nevirapine Tablets
- Kisqali (400 MG Dose)-New Day
- Kisqali (400 MG Dose)-New Terocin
- Kisqali (400 MG Dose)-Nexa Plus
- Nevirapine Extended-Release Tablets-Kisqali (600 MG Dose)
- Nevirapine Extended-Release Tablets-Kisqali Femara Co-Pack
- Nevirapine Extended-Release Tablets-Kisqali Femara Co-Pack 200 mg-2.5 mg Dose
- Nevirapine Extended-Release Tablets-Kisqali Femara Co-Pack 400 mg-2.5 mg Dose
- Nevirapine Extended-Release Tablets-Kisqali Femara Co-Pack 600 mg-2.5 mg Dose
- Nevirapine Extended-Release Tablets-Kitabis Pak