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Korlym and Prevymis

Determining the interaction of Korlym and Prevymis and the possibility of their joint administration.

Check result:

Korlym <> Prevymis

Relevance: 13.03.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Letermovir may increase the blood levels and effects of miFEPRIStone. This may increase the risk and/or severity of side effects, particularly if you are on miFEPRIStone for a prolonged period. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of mifepristone, which is primarily metabolized by the isoenzyme. The clinical impact of this interaction has not been studied.

MANAGEMENT: Due to its potent antiglucocorticoid effects and potential to cause dose-related prolongation of the QT interval, caution is advised if mifepristone is prescribed in combination with CYP450 3A4 inhibitors, particularly when used daily to control hyperglycemia secondary to hypercortisolism in patients with endogenous Cushing's syndrome.

References

"Product Information. Mifeprex (mifepristone)" Danco Laboratories, New York, NY.
"Product Information. Korlym (mifepristone)." Corcept Therapeutics Incorporated, Menlo Park, CA.

Korlym

Generic Name: mifepristone

Brand name: Korlym, Mifeprex

Synonyms: n.a.

What is Korlym?

Prevymis

Generic Name: letermovir

Brand name: Prevymis

Synonyms: n.a.

What is Prevymis?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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