Labetalol and Silenor

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Labetalol may increase the blood levels of doxepin. You may need dose adjustments or monitoring in order to safely take both medications together. You should notify your doctor if you have symptoms such as: tremor, low blood pressure, dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention or dizziness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Limited data suggest that labetalol can increase the plasma concentrations of tricyclic antidepressants. The proposed mechanism is competition for the same metabolic pathway. In a study (n=13), imipramine AUC increased by 53% in subjects taking labetalol compared to placebo. The manufacturers of labetalol indicate that concomitant use with tricyclic antidepressants may increase the incidence of tremors and hypotensive events. Carvedilol may also interact similarly.

MANAGEMENT: Close monitoring for clinical response and tolerance is recommended whenever labetalol is added to or discontinued from an antidepressant regimen. Patients should be advised to notify their physician if they experience excessive antidepressant effects such as tremor, dry mouth, blurry vision, irregular or fast heartbeat, constipation, urinary retention, dizziness, or hypotension. Dose adjustments may be necessary.

Labetalol

Generic Name: labetalol

Brand name: Trandate, Normodyne

Synonyms: n.a.

What is Labetalol?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?