Lacosamide Oral Solution and Namzaric
Determining the interaction of Lacosamide Oral Solution and Namzaric and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Donepezil can occasionally cause excessively slow heart rate and low blood pressure, and using it with lacosamide may increase that risk. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or irregular heartbeat during treatment with these drugs, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Since acetylcholinesterase inhibitors can cause bradycardia and heart block due to vagotonic effects on the sinoatrial and atrioventricular nodes, additive effects may occur with other agents that also possess bradycardic effects such as beta-blockers, calcium channel blockers, digitalis, some protease inhibitors (atazanavir, lopinavir-ritonavir, saquinavir), amiodarone, dronedarone, moricizine, lacosamide, and mefloquine. A group of French investigators conducted a retrospective analysis of spontaneous reports in the French Pharmacovigilance Database concerning adverse drug reactions (ADRs) associated with use of the acetylcholinesterase inhibitors donepezil, galantamine, and rivastigmine. Two hundred and five cases of potential drug-drug interaction with bradycardic drugs (beta-blockers, calcium channel blockers, amiodarone, digoxin) were identified, 73 of which were associated with serious ADRs including five deaths due to syncope, bradycardia, arrhythmia, or cardiac arrest. However, no details on the individual cases such as patient characteristics or concomitant risk factors were provided, making the contribution of a potential drug interaction difficult to evaluate. The remainder of the cases were of no apparent clinical consequences. In contrast, a phase III trial of donepezil consisting of 1035 patients reported no significant increase in risk ratios for bradycardia during concomitant use of beta-blockers, nondihydropyridine calcium channel blockers, or digoxin.
MANAGEMENT: Caution is advised if acetylcholinesterase inhibitors are used concomitantly with bradycardic drugs. Patients with underlying structural heart disease, preexisting conduction system abnormalities, ischemic heart disease, or cardiomyopathies may be at increased risk for developing cardiac conduction disturbances and atrioventricular block. Patients should be advised to notify their physician if they experience dizziness, lightheadedness, fainting, or irregular heartbeat.
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- "Product Information. Cognex (tacrine)." Parke-Davis, Morris Plains, NJ.
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- "Product Information. Aricept (donepezil)." Pfizer US Pharmaceuticals, New York, NY.
- "Product Information. Razadyne (galantamine)." Johnson and Johnson Medical Inc, Arlington, TX.
Generic Name: lacosamide
Brand name: Vimpat
Synonyms: Lacosamide (oral/injection), Lacosamide
Generic Name: donepezil / memantine
Brand name: Namzaric, Namzaric Titration Pack
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lacosamide Oral Solution-Namzaric Titration Pack
- Lacosamide Oral Solution-Nandrolone
- Lacosamide Oral Solution-NanoVM 1-3 Years
- Lacosamide Oral Solution-NanoVM 4-8 Years
- Lacosamide Oral Solution-Naphazoline
- Lacosamide Oral Solution-Naphazoline and Antazoline (Ophthalmic)
- Namzaric-Lacosamide oral/injection
- Namzaric-Lacosamide Tablets
- Namzaric-Lacticare-HC
- Namzaric-Lactulose
- Namzaric-Lactulose Oral Solution
- Namzaric-Lactulose Powder for Oral Solution