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Lamictal XR and Rheumatrex Dose Pack Oral

Determining the interaction of Lamictal XR and Rheumatrex Dose Pack Oral and the possibility of their joint administration.

Check result:

Lamictal XR <> Rheumatrex Dose Pack Oral

Relevance: 20.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Lamotrigine is a weak inhibitor of dihydrofolate reductase. Theoretically, coadministration with other dihydrofolate reductase inhibitors may have additive effects on rapidly proliferating tissues such as bone marrow, possibly increasing the risk of megaloblastic anemia and other hematologic adverse effects. However, a clinically significant interaction has not been reported. During prolonged human dosing, lamotrigine did not induce significant changes in the hemoglobin concentration, mean corpuscular volume, or serum or red blood cell folate concentrations for up to one year. No significant effects on red blood cell folate concentration have been observed for up to five years.

References

"Product Information. Lamictal (lamotrigine)." Glaxo Wellcome, Research Triangle Park, NC.

Lamictal XR

Generic Name: lamotrigine

Brand name: Lamictal, Lamictal ODT, Lamictal XR, Subvenite, Lamictal, Lamictal ODT, Lamictal XR, Lamictal CD, LaMICtal Starter Kit, LaMICtal ODT Patient Titration Kit, LaMICtal XR Patient Titration Kit, LamoTRIgine Starter Kit, Subvenite Starter Kit

Synonyms: n.a.

What is Lamictal XR?

Rheumatrex Dose Pack Oral

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: Rheumatrex Dose Pack, Rheumatrex

What is Rheumatrex Dose Pack Oral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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