Lamictal XR and Zyprexa Zydis
Determining the interaction of Lamictal XR and Zyprexa Zydis and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with olanzapine may slightly decrease the plasma concentrations of lamotrigine. The mechanism of interaction has not been described. In 16 healthy male volunteers, addition of olanzapine (15 mg once daily) decreased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of lamotrigine (200 mg once daily) by 20% and 24%, respectively, compared to administration of lamotrigine alone in 12 healthy male volunteers. These alterations are unlikely to be of clinical significance. In another study, olanzapine 5 mg had no effect on the Cmax and AUC of lamotrigine (25 mg daily for 5 days, then 50 mg daily for 13 days) in 14 healthy volunteers, but significantly increased the mean time to reach peak plasma concentration (Tmax) of lamotrigine from 1.9 to 4.0 hours. This effect may be attributable to the anticholinergic properties of olanzapine. Mild sedation was the only adverse effect reported during lamotrigine and olanzapine coadministration. Lamotrigine has no effect on the pharmacokinetics of olanzapine.
- "Product Information. Lamictal (lamotrigine)." Glaxo Wellcome, Research Triangle Park, NC.
- Jann MW, Hon YY, Shamsi SA, Zheng J, Awad EA, Spratlin V "Lack of pharmacokinetic interaction between lamotrigine and olanzapine in healthy volunteers." Pharmacotherapy 26 (2006): 627-33
Generic Name: lamotrigine
Brand name: Lamictal, Lamictal ODT, Lamictal XR, Subvenite, Lamictal, Lamictal ODT, Lamictal XR, Lamictal CD, LaMICtal Starter Kit, LaMICtal ODT Patient Titration Kit, LaMICtal XR Patient Titration Kit, LamoTRIgine Starter Kit, Subvenite Starter Kit
Synonyms: n.a.
Generic Name: olanzapine
Brand name: Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular, Zyprexa Relprevv
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Lamictal XR-Zyrtec
- Lamictal XR-Zyrtec (Cetirizine Capsules and Tablets)
- Lamictal XR-Zyrtec (Cetirizine Chewable Tablets)
- Lamictal XR-Zyrtec (Cetirizine Orally Disintegrating Tablets)
- Lamictal XR-Zyrtec (Cetirizine Syrup)
- Lamictal XR-Zyrtec Capsule
- Zyprexa Zydis-Lamisil
- Zyprexa Zydis-Lamisil Oral Granules
- Zyprexa Zydis-Lamivudine
- Zyprexa Zydis-Lamivudine and tenofovir
- Zyprexa Zydis-Lamivudine and Tenofovir Disoproxil Fumarate
- Zyprexa Zydis-Lamivudine and zidovudine