Drug search by name

Lamisil and Nizoral

Determining the interaction of Lamisil and Nizoral and the possibility of their joint administration.

Check result:

Lamisil <> Nizoral

Relevance: 09.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ketoconazole may increase the blood levels and effects of terbinafine. This can increase the risk and/or severity of side effects including diarrhea, upset stomach, depression, taste or smell disturbances, and rarely, liver damage or low white blood cell counts (which can lead to infections). You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should seek immediate medical attention if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Inhibitors of CYP450 2C9 and 3A4 may increase the systemic exposure to terbinafine. In a clinical study, coadministration of single doses of fluconazole 100 mg and terbinafine 750 mg increased the maximum plasma concentration and AUC of terbinafine by 52% and 69%, respectively. Although clinical data are lacking, amiodarone and ketoconazole may also significantly increase the systemic exposure to terbinafine.

MANAGEMENT: It is advisable to monitor patients for side effects during coadministration, such as diarrhea, abdominal pain, liver function test abnormalities, rashes, urticaria, and pruritus.

References

Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
"Product Information. Diflucan (fluconazole)." Roerig Division, New York, NY.

Lamisil

Generic Name: terbinafine

Brand name: Lamisil, Terbinex

Synonyms: n.a.

What is Lamisil?

Nizoral

Generic Name: ketoconazole

Brand name: Nizoral

Synonyms: n.a.

What is Nizoral?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions