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Lamivudine and zidovudine and Tivorbex

Determining the interaction of Lamivudine and zidovudine and Tivorbex and the possibility of their joint administration.

Check result:

Lamivudine and zidovudine <> Tivorbex

Relevance: 28.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using zidovudine together with indomethacin may increase the risk of bleeding in HIV-positive patients with hemophilia. However, the interaction is not fully understood, and evidence is limited. Talk to your doctor or pharmacist if you have any concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited clinical data suggest that the concomitant use of zidovudine with nonsteroidal anti-inflammatory agents may increase the risk of hematological toxicity and/or bleeding in HIV-positive patients with hemophilia. The mechanism is unknown.

MANAGEMENT: It is recommended to monitor patients for side effects and bleeding during concomitant use.

References

Barry M, Howe J, Back D, et al "The effects of indomethacin and naproxen on zidovudine pharmacokinetics." Br J Clin Pharmacol 36 (1993): 82-5
Sim SM, Back DJ, Breckenridge AM "The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes." Br J Clin Pharmacol 32 (1991): 17-21
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0

Lamivudine and zidovudine

Generic Name: lamivudine / zidovudine

Brand name: Combivir

Synonyms: Lamivudine and Zidovudine

What is Lamivudine and zidovudine?

Tivorbex

Generic Name: indomethacin

Brand name: Indocin, Indocin SR, Tivorbex

Synonyms: n.a.

What is Tivorbex?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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